abstract：:A majority of birds are socially monogamous, providing exceptional opportunities to discover neuroendocrine mechanisms underlying preferences for opposite-sex partners where the sexes form extended affiliative relationships. Zebra finches have been the focus of the most systematic program of research to date in any so...

journal_title：Frontiers in neuroendocrinology

authors： Adkins-Regan E

更新日期：2011-04-01 00:00:00

abstract：:Female sexual behavior in rodents, typified by the lordosis posture, is hormone-dependent and sex-specific. Ovarian hormones control this behavior via receptors in the hypothalamic ventromedial nucleus (VMH). This review considers the sex differences in the morphology, neurochemistry and neural circuitry of the VMH to...

journal_title：Frontiers in neuroendocrinology

authors： Flanagan-Cato LM

更新日期：2011-04-01 00:00:00

abstract：:The majority of songbird species have sexually dimorphic neuronal circuits for song learning and production and these differences are paralleled by sex differences in behavior, with only males singing or singing at a higher rate than females. Therefore songbirds serve as an excellent model for studying the mechanisms ...

journal_title：Frontiers in neuroendocrinology

authors： Duncan KA,Carruth LL

更新日期：2011-01-01 00:00:00

abstract：:Most human obesity is inherited as a polygenic trait which is largely refractory to medical therapy because obese individuals avidly defend their elevated body weight set-point. This set-point is mediated by an integrated neural network that controls energy homeostasis. Epidemiological studies suggest that perinatal a...

journal_title：Frontiers in neuroendocrinology

authors： Levin BE

更新日期：2010-07-01 00:00:00

abstract：:Glutamate synapses drive the output of neuroendocrine cells in the hypothalamus, but until recently, relatively little was known about the fundamental properties of transmission at these synapses. Here we review recent advances in the understanding of glutamate signals in magnocellular neurosecretory cells (MNCs) in t...

journal_title：Frontiers in neuroendocrinology

authors： Iremonger KJ,Benediktsson AM,Bains JS

更新日期：2010-07-01 00:00:00

abstract：:Identification of novel neurohormones that regulate the reproductive axis is essential for the progress of neuroendocrinology. The decapeptide gonadotropin-releasing hormone (GnRH) is the primary factor responsible for the hypothalamic control of gonadotropin secretion. Gonadal sex steroids and inhibin modulate gonado...

journal_title：Frontiers in neuroendocrinology

authors： Tsutsui K,Bentley GE,Bedecarrats G,Osugi T,Ubuka T,Kriegsfeld LJ

更新日期：2010-07-01 00:00:00

abstract：:Molecular modifications to the structure of histone proteins and DNA (chromatin) play a significant role in regulating the transcription of genes without altering their nucleotide sequence. Certain epigenetic modifications to DNA are heritable in the form of genomic imprinting, whereby subsets of genes are silenced ac...

journal_title：Frontiers in neuroendocrinology

authors： Keverne EB,Curley JP

更新日期：2008-06-01 00:00:00

abstract：:Trans-generational epigenetic phenomena, such as contamination with endocrine-disrupting chemicals (EDCs) that decrease fertility and the global methylation status of DNA in the offspring, are of great concern because they may affect health, particularly the health of children. However, of even greater concern is the ...

journal_title：Frontiers in neuroendocrinology

authors： Ruden DM,Jamison DC,Zeeberg BR,Garfinkel MD,Weinstein JN,Rasouli P,Lu X

更新日期：2008-06-01 00:00:00

abstract：:The ability of a species to reproduce successfully requires the careful orchestration of developmental processes during critical time points, particularly the late embryonic and early postnatal periods. This article begins with a brief presentation of the evidence for how gonadal steroid hormones exert these imprintin...

journal_title：Frontiers in neuroendocrinology

authors： Gore AC

更新日期：2008-06-01 00:00:00

abstract：:Mounting evidence suggests that--beyond the well-known genomic effects--glucocorticoids affect cell function via non-genomic mechanisms. Such mechanisms operate in many major systems and organs including the cardiovascular, immune, endocrine and nervous systems, smooth and skeletal muscles, liver, and fat cells. Non-g...

journal_title：Frontiers in neuroendocrinology

authors： Haller J,Mikics E,Makara GB

更新日期：2008-05-01 00:00:00

abstract：:Male mammals of many species exhibit reflexive testosterone release in mating situations. In house mice (Mus musculus), the dramatic robustness of such release, occurring primarily in response to a novel female, suggests some function. The resulting testosterone elevations typically peak during copulatory behavior and...

journal_title：Frontiers in neuroendocrinology

authors： Nyby JG

更新日期：2008-05-01 00:00:00

abstract：:In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and m...

journal_title：Frontiers in neuroendocrinology

authors： Scharfman HE,MacLusky NJ

更新日期：2006-12-01 00:00:00

abstract：:In addition to its well documented action in female-typical behaviors, progesterone exerts an influence on the brain and behavior of males. This review will discuss the role of progesterone and its receptor in male-typical reproductive behaviors in adulthood and the role of progesterone and its receptor in neural deve...

journal_title：Frontiers in neuroendocrinology

authors： Wagner CK

更新日期：2006-09-01 00:00:00

abstract：:Initial investigations into the mechanistic basis of aggression focused on the role of testosterone (T) and a variety of studies on non-human animals found that elevated T levels promote aggression. However, many correlational studies have not detected a significant association between aggression and peripheral T leve...

journal_title：Frontiers in neuroendocrinology

authors： Trainor BC,Kyomen HH,Marler CA

更新日期：2006-07-01 00:00:00

abstract：:Rapid, non-transcriptionally mediated, effects of glucocorticoids affect many behaviors as well as inhibition of function in the hypothalamo-pituitary-adrenal axis. In this short review, it is argued that the fast glucocorticoid actions which are mediated by membrane receptors are an ancient type of sterol/steroid-med...

journal_title：Frontiers in neuroendocrinology

authors： Dallman MF

更新日期：2005-10-01 00:00:00

abstract：:Appropriate regulatory control of the hypothalamo-pituitary-adrenocortical stress axis is essential to health and survival. The following review documents the principle extrinsic and intrinsic mechanisms responsible for regulating stress-responsive CRH neurons of the hypothalamic paraventricular nucleus, which summate...

journal_title：Frontiers in neuroendocrinology

authors： Herman JP,Figueiredo H,Mueller NK,Ulrich-Lai Y,Ostrander MM,Choi DC,Cullinan WE

更新日期：2003-07-01 00:00:00

abstract：:The majority of pituitary adenomas are trophically stable and change relatively little in size over many years. A comparatively small proportion behave more aggressively and come to clinical attention through inappropriate hormone secretion or adverse effects on surrounding structures. True malignant behaviour with me...

journal_title：Frontiers in neuroendocrinology

authors： Levy A,Lightman S

更新日期：2003-04-01 00:00:00

abstract：:Gene therapy, which entails the use of nucleic acids as drugs, is a new approach to treat disease. Gene therapy has been successfully implemented in several preclinical animal models, including several paradigms of experimental pituitary tumors. In spite of these successes, several critical issues need to be addressed...

journal_title：Frontiers in neuroendocrinology

authors： Castro M,Goverdhana S,Hu J,Jovel N,Yuan X,Lowenstein P

更新日期：2003-01-01 00:00:00

abstract：:In order to fulfill their roles in neuroendocrine regulation, specific hypothalamic neurons are devoted to produce and deliver biologically active peptides to the pituitary gland. The biosynthesis and release of peptides are strictly controlled by afferents to these hypothalamic neurons. Cell-specific expression and b...

journal_title：Frontiers in neuroendocrinology

authors： Burbach JP

更新日期：2002-10-01 00:00:00

abstract：:Insight into the mechanisms of action of neurotrophic growth factors has been obtained through the identification and characterization of gene products that are regulated or modified at the transcriptional, translational, and/or posttranslational level in response to neurotrophin treatment. VGF (non-acronymic) was ide...

journal_title：Frontiers in neuroendocrinology

authors： Salton SR,Ferri GL,Hahm S,Snyder SE,Wilson AJ,Possenti R,Levi A

更新日期：2000-07-01 00:00:00

abstract：:A simple method of manipulating neuronal gene expression would greatly facilitate the design of experiments to increase our understanding of and ability to treat diseases of the CNS. However, until recently most transfection methods could only deliver DNA into dividing cells and it was only possible to manipulate neur...

journal_title：Frontiers in neuroendocrinology

authors： Geddes BJ,Harding TC,Lightman SL,Uney JB

更新日期：1999-10-01 00:00:00

abstract：:This review examines recent advances in the study of the behavioral responses to deficits of body water and body sodium that in humans are accompanied by the sensations of thirst and salt appetite. Thirst and salt appetite are satisfied by ingesting water and salty substances. These behavioral responses to losses of b...

journal_title：Frontiers in neuroendocrinology

authors： Johnson AK,Thunhorst RL

更新日期：1997-07-01 00:00:00

abstract：:The pulsatile release of gonadotropin-releasing hormone (GnRH) into the portal vasculature is responsible for the maintenance of reproductive function. Levels of GnRH decapeptide available for this process can be regulated at transcriptional, posttranscriptional, and posttranslational levels. In the immortalized neuro...

journal_title：Frontiers in neuroendocrinology

authors： Gore AC,Roberts JL

更新日期：1997-04-01 00:00:00

abstract：:Some 10 years have elapsed since inhibins were first isolated from ovarian follicular fluid and characterized as disulphide-linked dimeric glycoproteins capable of selectively suppressing the synthesis and secretion of follicle-stimulating hormone (FSH) by pituitary gonadotropes. There have been numerous surprises sub...

journal_title：Frontiers in neuroendocrinology

authors： Knight PG

更新日期：1996-10-01 00:00:00

abstract：:A 37-kDa corticotropin releasing factor (CRF) binding protein (CRF-BP) was purified from human plasma by repeated affinity purification and subsequently sequenced and cloned. The human and rat CRF-BP cDNAs encode proteins of 322 amino acids with one putative signal sequence, one N-glycosylation site, and 10 conserved ...

journal_title：Frontiers in neuroendocrinology

authors： Behan DP,De Souza EB,Lowry PJ,Potter E,Sawchenko P,Vale WW

更新日期：1995-10-01 00:00:00

abstract：:Two different approaches have been utilized to study the controlling mechanisms that underlie the generation and entrainment of circadian rhythms in mammals. The use of specific drugs to alter the period and/or the phase of circadian rhythms has provided new insights into both the pathways by which environmental infor...

journal_title：Frontiers in neuroendocrinology

authors： Turek FW,Pinto LH,Vitaterna MH,Penev PD,Zee PC,Takahashi JS

更新日期：1995-07-01 00:00:00

abstract：:The immune system and the hypothalamic-pituitary (H-P) axis are functionally connected, so that exposure to antigens elicits a coordinated response which allows the organism to successfully withstand immunologic challenges. An important feature of this bilateral communication is the appearance of proteins released int...

journal_title：Frontiers in neuroendocrinology

authors： Rivier C

更新日期：1995-04-01 00:00:00

abstract：:A rapidly growing body of evidence reveals that complex networks of communication exist between the neuroendocrine and the immune systems. Essential to the maintenance and function of the immune-endocrine circuitry are an array of chemical mediators produced by cells of the immune and endocrine systems. Cytokines are ...

journal_title：Frontiers in neuroendocrinology

authors： Spangelo BL,Gorospe WC

更新日期：1995-01-01 00:00:00

abstract：:The area postrema (AP) has been implicated as a chemoreceptor trigger zone for vomiting (emesis) for over 40 years. The AP is located on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle. It is one of the so-called circumventricular organs that serve as an interface between the brai...

journal_title：Frontiers in neuroendocrinology

authors： Miller AD,Leslie RA

更新日期：1994-12-01 00:00:00

abstract：:There is considerable evidence that the central nervous system (CNS) is significantly involved in potassium homeostasis: (a) Potassium-specific receptors located in the liver or hepatic portal circulation initiate a reflex increase in potassium excretion via vagal afferents. This reflex is lost or diminished with hypo...

journal_title：Frontiers in neuroendocrinology

authors： Rabinowitz L,Aizman RI

更新日期：1993-01-01 00:00:00

abstract：:Clinical introduction of octreotide, a long-acting somatostatin analog, has opened a new era in the medical therapy of patients with growth hormone (GH)- and thyroid-stimulating hormone (TSH)-secreting pituitary tumors. Good control of hormonal hypersecretion occurred in most patients, and tumor shrinkage has been obs...

journal_title：Frontiers in neuroendocrinology

authors： Lamberts SW,Hofland LJ,de Herder WW,Kwekkeboom DJ,Reubi JC,Krenning EP

更新日期：1993-01-01 00:00:00

abstract：:The natriuretic peptide system consists of three endogenous ligands, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), and at least three subtypes of receptors. All of the peptides and receptors exist in the central nervous system (CNS). ANPs in the brain ar...

journal_title：Frontiers in neuroendocrinology

authors： Imura H,Nakao K,Itoh H

更新日期：1992-07-01 00:00:00

abstract：:The concept is proposed that polypeptide neurotrophic factors contribute to the developmental regulation of ovarian and hypothalamic function in mammals. Nerve growth factor (NGF) and neurotrophin-3, two members of the neurotrophin family, have been identified in the rat ovary and one of its receptors has been localiz...

journal_title：Frontiers in neuroendocrinology

authors： Ojeda SR,Dissen GA,Junier MP

更新日期：1992-04-01 00:00:00